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Analysis of serious weight gain in patients using alectinib for ALK positive lung cancer, semaglutide a potential treatment for serious weight gain from ALK tyrosine kinase inhibitors

Effects on body weight DPP-4 inhibitors are weight-neutral, and thus they may be an attractive option for some patients if other options would likely cause additional weight gain

This delayed emptying contributes to increased satiety and reduced appetite, which supports weight loss but can also produce gastrointestinal side effects

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The calculator uses these factors alongside published dose-response curves from the STEP and SURMOUNT trial programs to estimate your trajectory